Vitamin D, obesity and cardiorenal risk in children

Н. Б. Куприенко^{1, 2}, Н. Н. Смирнова^{1, 2}

Authors: N. B. Kuprienko 1 2, N. N. Smirnova 1 2

Place: St Petersburg, Russia

Institution:
1 Federal North-West Medical Research Centre, St Petersburg, Russia
2 First Pavlov State Medical University of St. Petersburg, St Petersburg, Russia

Abstract: The article reviews some pleiotropic effects of vitamin D, shows that plasma level of 25 (OH)D is an indicator of organism supplement with vitamin D. Also some issues of vitamin D toxicity are discussed. Novel ideas about structure and functions of vitamin D-receptor, regulation of vitamin D-dependent genes expression are presented. Adipogenic activity of vitamin D, the role of its metabolites, vitamin D-connecting protein, fibroblast growth factor-23 in regulation of lipid, carbohydrate and energy metabolism are discussed. The paper summarizes the data from pilot and clinical studies of vitamin D deficiency and its influence on the development of insulin resistance, cardiovascular and kidney diseases. Possible ways of clinical use of vitamin D as a renoprotector and modulator of renin-angiotensin system are shown, along with the modulating effects of gene cluster associated with obesity (FTO) in children. Further investigations aimed at the practical recommendations development regarding the use of vitamin D in obesity and a metabolic syndrome in children are anticipated.  

Keywords: vitamin D, obesity, cardiorenal disorders, children

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