Сentral aortic pressure and augmentation index in young adults with regard to cardiovascular risk factors

М. Е. Евсевьева, О. В. Сергеева, В. Н. Добросельский, М. В. Еремин, М. В. Ростовцева, И. Ю. Галькова, Т. А. Смирнова, М. В. Литвинова

Authors: M. E. Evsevyeva, O. V. Sergeeva, V. N. Dobroselskiy, M. V. Eremin, M. V. Rostovtseva, I. Y. Galkova, T. A. Smirnova, M. V. Litvinova

Place: Stavropol, Russia

Institution: Stavropol State Medical University

Abstract: objective. To estimate central aortic blood pressure (BP) and index of augmentation in young people, taking into account the presence of risk factors (RF), during preventive medical examination. Design and methods. Altogether 78 students of 3-4 years, aged 19-23 years old have been surveyed within the framework of the regular medical examinations, at the Center of Students’ Health, Stavropol State Medical University, as a part of the project “University is the territory of health”. Besides RF assessment, central aortic pressure was evaluated by oscillometric method (BPLab, “Peter Telegin”, Novosibirsk, Russia; Vasotens Office). In addition to common peripheral BP parameters, this technology provides measurements of systolic BP aortic (SYSао), diastolic BP aortic ф1Аао), pulse BP aortic (PPао), average BP aortic (ABPао), left ventricular ejection duration (ED), augmentation index in aorta (А1хао), pulse pressure amplification (PPA) and subendocardial viability ratio (SEVR). Surveyed students were distributed into two groups: first group — without RF (control group), and second group — with RF (main group). For automatic tubulation of all parameters we used the operational system BPStat ® version 05.00.04 (“Petr Telegin”). For statistical data processing program “Statistica 8” was used. Results. At young age RF are associated with the increase of both peripheral and aortic BP, especially systolic and pulse ВР, as well as augmentation index of central ВР. In students RF are associated with the increase of aortic BP (isolated central or masked hypertension/prehypertensionwith the simultaneous increase of both peripheral and aortic BP). The frequency of isolated increase of peripheral BP among students with RF is similar to that in students without RF. conclusions. Thus, planimetric analysis of central pulse wave in young people allows to define various mechanisms leading to the early BP increase. These data enable differentiated premorbid diagnostics of hemodynamic status in young adults with cardiovascular RF. This approach will contribute to the more individualized preventive measures in young population.  

Keywords: young adults, central аortic pressure, risk factors

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