Expression of NAP 22 mRNA in kidney of spontaneously hypertensive rats (SHR line) and normotensive rats (wKY line) in early postnatal ontogenesis under normal exogenous calcium intake and its deficit

А.С. Альдекеева^{1, 2}, Н.А. Корнева², Е.Д. Руденко¹, Н.З. Клюева¹

Authors: A.S. Aldekeeva(1, 2), N.A. Korneva(2), E.D. Rudenko(2), N.Z. Klueva(1)

Place: St Petersburg, Russia

Institution: 1) Pavlov Institute of Physiology of Russian Academy of Sciences
2) The Institute of Analytical Instrument Making

Abstract: In kidney of spontaneously hypertensive rats in early postnatal ontogenesis, we studied the changes in the expression of NAP-22 quantitatively predominant protein kinase C substrate mRNA, which served us as an indicator of the severity of disruption in cell apparatus. Exogenous calcium deficiency increased the expression of NAP-22 mRNA. Based on the changes in the expression level of this protein, it can be resumed that disorders of kidney function precede the formation of lasting hypertension in the animals.  

Keywords: spontaneously hypertensive rats (SHR), kidney, early postnatal ontogenesis, protein NAP-22, calcium deficiency

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