Changes of the sympathetic activity in the heart and vessels in the development of experimental vasorenal hypertension (2 kidneys — 1 clip)

Н. В. Кузьменко, Ю. И. Щербин, М. Г. Плисс, В. А. Цырлин

Authors: N. V. Kuzmenko, Y. I. Shcherbin, M. G. Pliss, V. A. Tsyrlin

Place: St Petersburg, Russia

Institution: Federal Almazov Medical Research Centre First Pavlov State Medical University of St. Petersburg,

Abstract: objective. To evaluate the dynamics of arterial blood pressure and sympathetic activity in the male Wistar rats within 8 weeks after renal artery clamping (model «2 kidneys — 1 clamp»). Design and methods. The sympathetic activity was examined by spectral analysis of the heart rate variability in the non-anaesthesized rats. The sympathetic vasomotor activity was examined by the registration of electric activity of the cervical spine cord in anaesthesized animals. Results. We found that sympathetic activity to the heart and blood vessels is comparable. Two weeks after renal artery clamping the activity of the sympathetic nervous system increases, and 4 weeks later it comes close to the reference values in the developed hypertension and then increases to maximum values by the end of the experiment. conclusions. Based on our results, the mechanism of hypertension after renal artery clipping, is fairly complex, but, in the end, it appears to be associated with the increased activity of vasomotor spinal cord neurons.  

Keywords: vasorenal hypertension, sympathetic activity, heart rate, spectral analysis

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