Clinical, laboratory and prognostic features of masked arterial hypertension in midlife working women

Н. П. Лямина, А. В. Наливаева, Л. И. Малинова, В. Н. Сенчихин

Authors: N. P. Lyamina, A. V. Nalivaeva, L. I. Malinova, V. N. Senchikhin

Place: Saratov, Russia

Institution: Research Institute for Cardiology, Saratov State Medical University named by V. I. Razumovsky, Saratov, Russia

Abstract: objective. Late detection and diagnostics of masked hypertension (MHTN) triggering cardiovascular continuum is still one of the key issues in healthcare system. Design and methods. We examined 309 midlife women (31-57 years old) working in institutions without specified factors of occupational hazards. We excluded patients with verified pathology, taking oral contraception or hormonotherapy. MHTN was verified based on the following criteria: combination of normal office blood pressure (BP) (< 140/90 mm Hg), positive breathhold test and elevated BP according to the results of 24-hour BP monitoring. Results and conclusions. MHTN was detected in 8,7 %. We defined clinical features of MHTN in examined population: absence of complaints and anamnesis of cardiovascular diseases, elevated mean haemodynamic pressure, and increased body mass index. Analysis of clinical and laboratory results showed no difference between mean parameters of lipid profile in the examined population, despite higher dyslipidemia rate among patients with hypertension and MHTN as compared to patients without hypertension (p < 0,05). The tendency towards elevation of fasting blood glucose and decreasing of glomerular filtration rate in patients with MHTN was not significantly different. Ten-year risk of fatal cardiovascular events (assessed by survival model based on Weibull function) in midlife working women with MHTN was comparable with women with manifest hypertension.

Keywords: masked hypertension, midlife women, clinical and laboratory features, prognosis

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