Peculiarities of chronic heart failure with preserved ejection fraction in patients with essential hypertension

Р.А. Либис, А.Г. Душина, Е.А. Олейник

Authors: R.A. Libis, A.G. Dushina, E.A. Oleynik

Place: Orenburg, Russia

Institution: Orenburg State Medical Academy

Abstract: Objective. To estimate clinical status, quality of life (QOL), physical activity, structural and functional peculiarities of the heart in patients with chronic heart failure with preserved ejection fraction (CHF-PEF). Design and methods. Seventy-two patients with CHF-PEF (age 47–77 years) were examined. Clinical status, QOL by Minnesota questionnaire, 6-minute walk test, heart ultrasound, serum N-terminal brain natriuretic propeptide level were assessed in all patients. Results. Main complaint was dyspnea at physical activity in patients with CHF-PEF (95,8 %). Structural and functional myocardium changes were more expressed in patients with higher functional class. General total score by Minnesota questionnaire was 21,5 [14,5; 40,0] in men and 48,5 [36,0; 59,0] in women. Tolerance to physical activity influenced QOL. Conclusions. All patients had echocardiographic signs of left ventricular diastolic dysfunction. The higher functional class of heart failure was associated with the more pronounced myocardial hypertrophy, decreased QOL and physical activity. QOL was higher in men, than in women. Diabetes mellitus, ischemic heart disease were associated with the clinical progression of CHF.

Keywords: chronic heart failure with preserved ejection fraction, diastolic dysfunction, quality of life

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