The prevalеnce of primary aldosteronism in patients with uncontrolled hypertension and in patients with previously detected adrenal incidentaloma: the database of antihypertensive specialized center

Н.Г. Авдонина, Н.Э. Звартау, И.В. Емельянов, Е.Ю. Васильева, О.А. Хохунов, С.А. Полехин, Е.Н. Гринёва, А.О. Конради

Authors: N.G. Avdonina, N.E. Zvartau, I.V. Emelianov, E.Yu. Vasilieva, O.A. Khokhunov, S.A. Polekhin, E.N. Grineva, A.O. Konradi

Place: St Petersburg, Russia

Institution: Federal Almazov Medical Research Centre

Abstract: Objective. To determine the prevalence of primary aldosteronism (PA) through routine practice — among patients visiting a specialized antihypertensive center due to uncontrolled hypertension or with adrenal incidentalomas. Design and methods. We included 314 patents with uncontrolled hypertension and 195 patients with incidentalomas. Aldosterone-renin ratio (ARR), hormonal tests and examination for exclusion of symptomatic hypertension were performed in all subjects. Results. PA diagnosis was confirmed in 27 patients with uncontrolled hypertension (8,6 % hypertensive patients) and in 17 % patients with adrenal incidentalomas. ARR increase as well as elevated aldosterone level were found in all subjects, and all of them had high PA risk. Conclusions. The prevalence of PA is 8,6 % patients with uncontrolled hypertension and 17 % patients with adrenal incidentalomas. ARR increase along with aldosterone level elevation should be considered at patient evaluation.

Keywords: primary aldosteronism, adrenal incidentaloma, uncontrolled hypertension, aldosterone-renin ratio

446.82 KB 0