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Metabolic syndrome and cognitive dysfunctions in older adults: women are a risk group

Е.А. Дубинина1,2, О.П. Ротарь3, Е.В. Могучая3, М.А. Бояринова3, Е.П. Колесова3, А.Ю. Селикова1, А.Н. Алёхин1, А.О. Конради3

Authors: E.A. Dubinina12, O.P. Rotar3, E.V. Moguchaia3, M.A. Boyarinova3, E.P. Kolesova3, A.Yu. Selikova 1, A.N. Alekhin1, A.O. Konradi3

Place: St Petersburg, Russia

Institution: 1 Russian Herzen State Pedagogical University, St Petersburg, Russia 2 St Petersburg Psychoneurological Research Institute n.a. V.M. Bekhterev, St Petersburg, Russia 3 Federal Almazov Medical Research Centre, St Petersburg, Russia

Abstract:

Objective. To determine relationship between metabolic syndrome (MS), its components and cognitive dysfunction among older adults. Design and methods. Altogether 196 subjects who did not have a history of cerebrovascular events (53 males, 143 females aged 64-86) — survivors of Leningrad Siege — were examined. IDF и АНА/NHLBI (2009) criteria for MS were used. Cognitive function was assessed applying Mini-Mental State Examination scale (MMSE). Results. MS was identified in 48 % subjects. The prevailing components were hypertension, central obesity, hyperglycemia. According to MMSE results there were no participants with signs of dementia, but in 40 % cognitive dysfunction of different degree was found. Memory and attention were most impaired. Total MMSE score was associated with decreased verbal auditory working memory in women of the age group < 70 years old (p < 0,05). Individual components of MS were associated with cognitive dysfunction, but only in women under or 70 years old. In this group participants with cardiometabolic disorders had the lowest scores at “Repetition” and “Sequence of actions” subscales. Hypertriglyceridemia was the component of MS most tightly associated with cognitive dysfunctions. Conclusions. Women with MS (especially with hypertriglyceridemia) are a risk group of cognitive dysfunctions.
 

Keywords: metabolic syndrome, old age, cognitive dysfunctions, hypertriglyceridemia, sex differences

 

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