Objective. To investigate the incidence, clinical and hemodynamic characteristics of orthostatic hypotension (OH) in young and middle-aged hypertensive (HTN) patients by the head-up tilt test in relation to target organ damage. Design and methods. Eighty-five patients with HTN aged 47,0 (39,0-52,0) years and 40 healthy people aged 46,5 (33,0-51,0) years were examined. Head-up tilt test by Westminster protocol was performed. Hemodynamic parameters during the head-up tilt test and prevalence of OH were determined. We evaluated the target organ damage and antihypertensive therapy regimen in HTN patients with OH. Results and conclusions. Tilt-induced OH was registered in 18,8 % of HTN patients and in 17,5 % of the control group (p > 0,05). In HTN patients the heart rate elevation during the test was lower than in healthy men [12,0 (7-19) and 16,0 (10-29) beats per minute; р < 0,01]. The myocardial mass [104,2 (94-112) и 88,5 (81-105) g/m2; р < 0,05] was higher and carotid wall [1,5 (0,7-2,3) и 0,6 (0,5-1,0) mm; р < 0,05] was thicker as well as the signs of carotid atherosclerosis were found more often (50 and 18,8 %; р < 0,05) in hypertensives with OH, in comparison to those without OH.

 

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